sars-cov mpro-in-2 — TargetMol Chemicals

Cat No.	Product Name	Targets
T72581	SARS-CoV MPro-IN-2
	SARS-CoV MPro-IN-2 effectively inhibits the SARS-CoV-2 main protease (M pro), crucial for the virus's replication and transcription in host cells, with an IC50 value of 72.07 nM. Given its significant role in processing ...
T63098	SARS-CoV-2 Mpro-IN-2
	SARS-CoV-2 MPro-IN-2 is a selective, low cytotoxic, non-covalent Mpro inhibitor with an IC50 value of 0.40 μM. SARS-CoV-2 Mpro-IN-2 showed good anti-SARS-CoV-2 effect with EC50 value of 1.1 μM. SARS-CoV-2 Mpro-IN-2 can b...
T60686	SARS-CoV-2 Mpro-IN-1
	SARS-CoV-2 Mpro-IN-1 (compound 16b-3) is a potent, selective and irreversible SARS-CoV-2 main protease (Mpro) inhibitor (IC 50 = 116 nM) [1].
T72451	SARS-CoV-2 Mpro-IN-6
	SARS-CoV-2 Mpro-IN-6 is a selective, covalent, and irreversible inhibitor of SARS-CoV-2 main protease (Mpro), exhibiting an inhibition concentration (IC50) of 0.18 μM. It does not inhibit human cathepsins B, F, K, and L ...
T72447	SARS-CoV-2 Mpro-IN-5
	SARS-CoV-2 Mpro-IN-5 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL) with IC50 values of 1800 nM and 145 nM, respectively. This compound demonstrates antiviral activity by inhibiting SARS-CoV-2...
T81210	SARS-CoV-2 Mpro-IN-12	SARS-CoV
	SARS-CoV-2 Mpro-IN-12 (compound D026) serves as an inhibitor of the main protease (Mpro) of SARS-CoV-2, exhibiting antiviral properties [1].	SARS-CoV
T79279	SARS-CoV-2 Mpro-IN-8	SARS-CoV
	SARS-CoV-2 Mpro-IN-8 (compound 6b) is an antiviral agent effective against SARS-CoV-2 [1].	SARS-CoV
T79278	SARS-CoV-2 Mpro-IN-7	SARS-CoV
	SARS-CoV-2 Mpro-IN-7 (compound 6g) effectively inhibits SARS-CoV-2 main protease (Mpro) with an IC50 value of 8.8 μM and exhibits a cytotoxic concentration (CC50) of 10 μM [1].	SARS-CoV
T72446	SARS-CoV-2 Mpro-IN-4
	SARS-CoV-2 Mpro-IN-4 is a dual inhibitor targeting Main Protease (M Pro) and Cathepsin L (CatL), exhibiting inhibition concentrations (IC50) of 900 nM and 60 nM, respectively. It demonstrates antiviral activity by effect...
T79515	SARS-CoV-2 Mpro-IN-10	SARS-CoV
	SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, exhibiting IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively. It is utilized in research focused on the SARS-CoV-2 virus [1].	SARS-CoV
T79455	SARS-CoV-2 Mpro-IN-9	SARS-CoV
	SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharma...	SARS-CoV
T72231	SARS-CoV-2/MERS Mpro-IN-2
	SARS-CoV-2/MERS Mpro-IN-2 is a potent inhibitor of the main proteases of SARS-CoV-2 and MERS, demonstrating IC50 values of 0.21 and 0.07 µM, respectively.
T72230	SARS-CoV-2/MERS Mpro-IN-1
	SARS-CoV-2/MERS Mpro-IN-1 is a potent inhibitor of the main proteases in SARS-CoV-2 and MERS, exhibiting IC50 values of 0.10 and 0.06 µM, respectively.
T37173	MPro Inhibitor 11a
	MProinhibitor 11a is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.053 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-i...
T12836	SARS-CoV-2-IN-1	Others
	SARS-CoV-2-IN-1 is a potent inhibitor of Mpro(SARS-CoV-2 Mpro, SARS-CoV Mpro and MERS-CoV Mpro with IC50s of 0.67, 0.90 and 0.58 μM, respectively).	Others
T38174	Mpro inhibitor N3 hemihydrate
	Mpro inhibitor N3 hemihydrate is a potent antagonist of the SARS-CoV-2 main protease (Mpro), demonstrating an EC50 of 16.77 μM against SARS-CoV-2. It exhibits specific inhibition of Mpro in a range of coronaviruses, incl...
T80636	SARS-CoV-2-IN-59	SARS-CoV
	SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule that inhibits SARS-CoV-2 by targeting its main protease (Mpro). It exhibits robust binding with Mpro residues (Met 165, Gln 166,...	SARS-CoV
T78895	TKB245	SARS-CoV
	TKB245 is a potent inhibitor of the SARS-CoV-2 main protease (Mpro), effectively inhibiting viral replication in VeroE6 cells [1].	SARS-CoV
T81203	SARS-CoV-2-IN-68	SARS-CoV
	SARS-CoV-2-IN-68 (compound 6C) is a covalent inhibitor of both SARS-CoV-2 PLpro and Mpro, exhibiting potent antiviral properties by targeting the Zn-finger domain of PLpro [1].	SARS-CoV
T72718	SARS-CoV-2-IN-36
	SARS-CoV-2-IN-36 is a potent inhibitor of SARS-CoV-2 Mpro (SARS-CoV), demonstrating an IC50 of 2.37 μM and a Kd of 1.19 μM in enzymatic assays. This compound exhibits antiviral activity against SARS-CoV-2 variants UC-107...